Pulupot tells the story of Eva (Justine Ferrer), a hardworking transsexual enterpreneur waiting for Edgardo (Gio Gapas), the love of her life while his life is currently enmeshed in a complicated relationship with Kiko (Justin de Leon), a possesive gay man. , a pragmatic sex worker Kristel (Echo Caceres) and his OFW girlfriend Cora (Joyce Acorda).